U.S. Full Prescribing Information | Medication Guide [Español] | Indications For Healthcare Professionals
To treat and to help prevent Deep Vein Thrombosis & Pulmonary Embolism
If You're Living with AFib Not Caused by a
Heart Valve Problem, You Have Questions
Recently Diagnosed
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What is AFib?

Atrial fibrillation (AFib) is the most common type of irregular heartbeat. There are two types of AFib: one caused by a heart valve problem, and one that's not. The majority of AFib is not caused by a heart valve problem. If you have AFib, the top chambers of the heart quiver (fibrillate) instead of fully contracting.

Try picturing your heart as a soft squeeze bottle filled with liquid. Now imagine pressing very quickly but lightly. You'd never get all the liquid out. In the same way, AFib not caused by a heart valve problem can allow blood to pool in your heart, which can cause clots to form. These clots can travel to the brain and lead to stroke.

An estimated 6.4 million people in the United States have AFib not caused by a heart valve problem. AFib increases your risk of stroke. Additionally, strokes caused by AFib tend to be more severe and more likely to be fatal compared to strokes not associated with AFib.

What Your Brain
Needs to Know
About Your Heart

AFib not caused by a heart valve problem can cause blood to pool in the heart. Pooling blood can form clots that travel to the brain and can lead to stroke. Watch to see how a clot in the heart can become a stroke in the brain.

3 Good Reasons to
Consider ELIQUIS

There are many reasons to ask your doctor about ELIQUIS (apixaban). Here are 3 important ones.

1
In a clinical trial, ELIQUIS (apixaban)
reduced the risk of stroke better
than warfarin.
2
ELIQUIS had less major bleeding
than warfarin. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding. ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death.
3
Unlike warfarin, there's no routine
blood testing.
Signs and Symptoms of Bleeding

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS.

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak
  • Please read additional Important Safety Information below.
  • If you would like to learn more about ELIQUIS, click here.

More Reasons to
Consider ELIQUIS

With ELIQUIS, you can eat the healthy
foods you enjoy

Unlike warfarin, there are no “watch outs” for certain foods
like green leafy vegetables, which are rich in vitamin K.
That’s because vitamin K does not interfere with how
ELIQUIS works. So you can eat whatever healthy foods
you like.

Also, ELIQUIS doesn't have to be timed to a meal. It may
be taken with or without food.

With ELIQUIS, there are no regular
dose adjustments

If you’re on warfarin, your dosage may be frequently
adjusted based on the results from routine blood testing.
ELIQUIS doesn’t require regular dose adjustments.

If you’re on ELIQUIS, make sure you take ELIQUIS exactly
as prescribed by your doctor. ELIQUIS comes in either a
5 mg or 2.5 mg tablet.

Most people will be prescribed 5 mg twice a day. However,
tell your doctor about all medications you take and your
medical history, as the lower dose may be appropriate for you.

Let's Discuss

Talking to your doctor about stroke risk due to AFib not caused by a heart valve problem and whether ELIQUIS (apixaban) may be right for you is an important step. We want to do everything possible to help you and your doctor make a decision that works for you.

So we put together a handy guide that includes some questions you may want to discuss with your doctor. Just click the button below to go to the doctor discussion page and download the guide.


Go to the Doctor
Discussion Page Now

Considering ELIQUIS
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ELIQUIS Is a Prescription Blood Thinner

With AFib not caused by a heart valve problem, the heart does not beat the way it should. This can lead to blood clots forming and increases the risk of stroke.

ELIQUIS is a prescription blood thinner (anticoagulant) that lowers the risk of stroke in people with AFib not caused by a heart valve problem. In a clinical trial, ELIQUIS was proven to reduce the risk of stroke better than warfarin in people with AFib not caused by a heart valve problem (also known as nonvalvular atrial fibrillation).

Selected Important Safety Information

Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death.

Please read additional Important Safety Information below.

3 Good Reasons to
Consider ELIQUIS

If you're on warfarin, it's quite possible that you've become used to routine blood testing, dose adjustments, and dietary restrictions. But at the same time, you may be curious to know if there's a better choice for you. There is.

Here are 3 good reasons why you should ask your doctor about ELIQUIS.

1
In a clinical trial, ELIQUIS (apixaban)
reduced the risk of stroke better
than warfarin.
2
ELIQUIS had less major bleeding
than warfarin. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding. ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death.
3
Unlike warfarin, there's no routine
blood testing.
Signs and Symptoms of Bleeding

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS.

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak
  • Please read additional Important Safety Information below.
  • If you would like to learn more about ELIQUIS, click here.

More Reasons to
Consider ELIQUIS

With ELIQUIS, you can eat the healthy
foods you enjoy

Unlike warfarin, there are no “watch outs” for certain foods
like green leafy vegetables, which are rich in vitamin K.
That’s because vitamin K does not interfere with how
ELIQUIS works. So you can eat whatever healthy foods
you like.

Also, ELIQUIS doesn't have to be timed to a meal. It may
be taken with or without food.

With ELIQUIS, there are no regular
dose adjustments

If you’re on warfarin, your dosage may be frequently
adjusted based on the results from routine blood testing.
ELIQUIS doesn’t require regular dose adjustments.

If you’re on ELIQUIS, make sure you take ELIQUIS exactly
as prescribed by your doctor. ELIQUIS comes in either a
5 mg or 2.5 mg tablet.

Most people will be prescribed 5 mg twice a day. However,
tell your doctor about all medications you take and your
medical history, as the lower dose may be appropriate for you.

Support and Offers
with ELIQUIS 360

If you’re considering ELIQUIS (apixaban), one other thing to consider is that ELIQUIS comes with ELIQUIS 360 Support. It’s support that gives you access to offers, information about insurance coverage, useful guidance, lifestyle tips, helpful information about AFib not caused by a heart valve problem, its increased risk of stroke, and ELIQUIS.

Support That's Centered Around You

  • Access to offers and insurance coverage information
  • Get helpful tips and interesting facts about your condition
  • Sign up to receive useful information about ELIQUIS

ELIQUIS 360 Support is designed with you in mind—it’s support that’s centered around you. And it’s free.

To learn more about ELIQUIS 360 Support, click here.

Let's Discuss

Talking to your doctor about stroke risk due to AFib not caused by a heart valve problem and whether
ELIQUIS (apixaban) may be right for you is an important step. We want to do everything possible to help you and your doctor make a decision that works for you.

So we put together a handy guide that includes some questions you may want to discuss with your doctor. Just click the button below to go to the doctor discussion page and download the guide.


Go to the Doctor
Discussion Page Now

Taking ELIQUIS
This introduction is customized for you. Click "Next" to keep reading through all 5 panels.

3 Good Reasons to
Think ELIQUIS

1
In a clinical trial, ELIQUIS (apixaban)
reduced the risk of stroke better
than warfarin.
2
ELIQUIS had less major bleeding
than warfarin. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding. ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death.
3
Unlike warfarin, there's no routine
blood testing.
Signs and Symptoms of Bleeding

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS.

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak
  • Please read additional Important Safety Information below.
  • If you would like to learn more about ELIQUIS, click here.

More Reasons to
Consider ELIQUIS

With ELIQUIS, you can eat the healthy
foods you enjoy

Unlike warfarin, there are no “watch outs” for certain foods
like green leafy vegetables, which are rich in vitamin K.
That’s because vitamin K does not interfere with how
ELIQUIS works. So you can eat whatever healthy foods
you like.

Also, ELIQUIS doesn't have to be timed to a meal. It may
be taken with or without food.

With ELIQUIS, there are no regular
dose adjustments

If you’re on warfarin, your dosage may be frequently
adjusted based on the results from routine blood testing.
ELIQUIS doesn’t require regular dose adjustments.

If you’re on ELIQUIS, make sure you take ELIQUIS exactly
as prescribed by your doctor. ELIQUIS comes in either a
5 mg or 2.5 mg tablet.

Most people will be prescribed 5 mg twice a day. However,
tell your doctor about all medications you take and your
medical history, as the lower dose may be appropriate for you.

Taking ELIQUIS

Before learning about taking ELIQUIS (apixaban), it's important to know who should not take ELIQUIS.

Who should not take ELIQUIS

ELIQUIS is not for patients with artificial heart valves. Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a serious allergic reaction to ELIQUIS. Ask your doctor if you are not sure.

Taking ELIQUIS

Be sure to take ELIQUIS exactly as prescribed by your doctor.

ELIQUIS is taken twice a day, with or without food. There are no food restrictions or “watch outs” for certain foods like leafy green vegetables with ELIQUIS. You can continue to enjoy eating the healthy foods you like.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Take ELIQUIS as prescribed by your doctor, twice a day
  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak

Please read additional Important Safety Information below.

If you would like to learn more about ELIQUIS,
click here.

More About Taking ELIQUIS

No routine blood tests like with warfarin

With ELIQUIS (apixaban), there is no need for routine blood testing, such as the INR test or INR monitoring. The INR test checks to see how fast the blood clots. Warfarin is a medication with a "narrow therapeutic range." This means that small changes in the medication level may have an impact on the time it takes for blood to clot. Since warfarin has a narrow therapeutic range, the INR test is needed to check a patient’s response to warfarin and to adjust the warfarin dose to keep the INR in the target range.

ELIQUIS does not have a narrow therapeutic range and, therefore, it is not required for patients taking ELIQUIS to have routine blood testing such as INR monitoring.

If you miss a dose

If you miss a dose of ELIQUIS, take it as soon as you remember. Do not take more than one dose of ELIQUIS at the same time to make up for a missed dose.

Keep your prescription filled

Do not run out of ELIQUIS. Refill your prescription before you run out.

Your doctor will decide how long you should take ELIQUIS. Do not stop taking it without first talking with your doctor. Stopping ELIQUIS may increase your risk of having a stroke.

If you take too much ELIQUIS, call your doctor or go to the nearest hospital emergency room right away.

Call your doctor or healthcare provider right away if you fall or injure yourself, especially if you hit your head. Your doctor or healthcare provider may need to examine you.

ELIQUIS 360 Offers
Support and Savings

We're glad you're here learning more about your medication, ELIQUIS (apixaban). Did you know that ELIQUIS comes with ELIQUIS 360 Support? It’s support that gives you access to offers, information about insurance coverage, useful guidance, lifestyle tips, helpful information about AFib not caused by a heart valve problem, its increased risk of stroke, and ELIQUIS.

Support That's Centered Around You

  • Access to offers and insurance coverage information
  • Get helpful tips and interesting facts about your condition
  • Sign up to receive useful information about ELIQUIS

ELIQUIS 360 Support is designed with you in mind—it’s support that's centered around you. And it’s free.

To get access to ELIQUIS 360 Support and see if you're eligible for offers, click the button below or call 1-855-ELIQUIS (354-7847), Monday-Friday, 8 AM - 8 PM (ET).

 

Sign Up Now for
ELIQUIS 360 Support & Offers

Know Someone with AFib?
This introduction is customized for you. Click "Next" to keep reading through all 6 panels.

What is AFib?

Atrial fibrillation (AFib) is the most common type of irregular heartbeat. There are two types of AFib: one caused by a heart valve problem, and one that's not. The majority of AFib is not caused by a heart valve problem. If you have AFib, the top chambers of the heart quiver (fibrillate) instead of fully contracting.

Try picturing the heart as a soft squeeze bottle filled with liquid. Now imagine pressing very quickly but lightly. You'd never get all the liquid out. In the same way, AFib not caused by a heart valve problem can allow blood to pool in the heart, which can cause clots to form. These clots can travel to the brain and lead to stroke.

An estimated 6.4 million people in the United States have AFib not caused by a heart valve problem. AFib increases your risk of stroke. Additionally, strokes caused by AFib tend to be more severe and more likely to be fatal compared to strokes not associated with AFib.

What Your Brain Needs to Know About Your Heart

AFib not caused by a heart valve problem can cause blood to pool in the heart. Pooling blood can form clots that travel to the brain and can lead to stroke. Watch to see how a clot in the heart can become a stroke in the brain.

3 Good Reasons to
Consider ELIQUIS

1
In a clinical trial, ELIQUIS (apixaban)
reduced the risk of stroke better
than warfarin.
2
ELIQUIS had less major bleeding
than warfarin. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding. ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death.
3
Unlike warfarin, there's no routine
blood testing.
Signs and Symptoms of Bleeding

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS.

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak
  • Please read additional Important Safety Information below.
  • If you would like to learn more about ELIQUIS, click here.

More Reasons to
Consider ELIQUIS

With ELIQUIS, you can eat the healthy
foods you enjoy

Unlike warfarin, there are no “watch outs” for certain foods
like green leafy vegetables, which are rich in vitamin K.
That’s because vitamin K does not interfere with how
ELIQUIS works. So you can eat whatever healthy foods
you like.

Also, ELIQUIS doesn't have to be timed to a meal. It may
be taken with or without food.

With ELIQUIS, there are no regular
dose adjustments

If you’re on warfarin, your dosage may be frequently
adjusted based on the results from routine blood testing.
ELIQUIS doesn’t require regular dose adjustments.

If you’re on ELIQUIS, make sure you take ELIQUIS exactly
as prescribed by your doctor. ELIQUIS comes in either a
5 mg or 2.5 mg tablet.

Most people will be prescribed 5 mg twice a day. However,
tell your doctor about all medications you take and your
medical history, as the lower dose may be appropriate for you.

Support and Offers with ELIQUIS 360

If someone you know is considering asking their doctor about ELIQUIS (apixaban), one other thing to consider is that ELIQUIS comes with ELIQUIS 360 Support. It’s support that gives you access to offers, information about insurance coverage, useful guidance, lifestyle tips, helpful information about AFib not caused by a heart valve problem, its increased risk of stroke, and ELIQUIS.

Support That's Centered Around You

  • Access to offers and insurance coverage information
  • Get helpful tips and interesting facts about your condition
  • Sign up to receive useful information about ELIQUIS

ELIQUIS 360 Support is designed with you in mind—it’s support that's centered around you. And it’s free.

To learn more about ELIQUIS 360 Support, click here.

Let's Discuss

Talking to the doctor about stroke risk due to AFib not caused by a heart valve problem and whether ELIQUIS (apixaban) may be the right treatment, is an important step. We want to do everything possible to help someone with AFib and their doctor make a decision that works for them.

So we put together a handy guide that includes some questions a person with AFib may want to discuss with their doctor. Just click the button below to go to the doctor discussion page and download the guide.


Go to the Doctor
Discussion Page Now

IMPORTANT SAFETY INFORMATION
  • For people taking ELIQUIS for atrial fibrillation: Do not stop taking ELIQUIS® (apixaban) without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
    ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.
  • ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood-clotting.
  • You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.
    While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
  • Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:
    • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
    • bleeding that is severe or you cannot control
    • red, pink, or brown urine; red or black stools (looks like tar)
    • coughing up or vomiting blood or vomit that looks like coffee grounds
    • unexpected pain, swelling, or joint pain
    • headaches, or feeling dizzy or weak
  • ELIQUIS (apixaban) is not for patients with artificial heart valves.
  • Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:
    • a thin tube called an epidural catheter is placed in your back to give you certain medicine
    • you take NSAIDs or a medicine to prevent blood from clotting
    • you have a history of difficult or repeated epidural or spinal punctures
    • you have a history of problems with your spine or have had surgery on your spine
  • If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.
  • Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a serious allergic reaction to ELIQUIS.
  • Before you take ELIQUIS, tell your doctor if you have kidney or liver problems, have any other medical condition, or have ever had bleeding problems. Tell your doctor if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.
  • Take ELIQUIS exactly as prescribed by your doctor. Take ELIQUIS twice every day with or without food, and do not change your dose or stop taking it unless your doctor tells you to. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.
  • Possible serious side effects include bleeding or a reaction to ELIQUIS itself. A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have sudden chest pain or chest tightness, have sudden swelling of your face or tongue, have trouble breathing, wheezing, or feeling dizzy or faint.

INDICATIONS

ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation, a type of irregular heartbeat, not caused by a heart valve problem.

ELIQUIS is a prescription medicine used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.

ELIQUIS is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

COUMADIN® is a registered trademark of Bristol-Myers Squibb Pharma Company. All other trademarks are property of their respective companies.

This independent, non-profit organization provides assistance to qualifying patients with financial hardship who generally have no prescription insurance.
Contact 1-800-736-0003 or visit www.bmspaf.org for more information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

SELECTED IMPORTANT SAFETY INFORMATION
  • Do not stop taking ELIQUIS® (apixaban) without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
    ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.
  • ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.
  • You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs